Novo Nordisk and C40 Cities are partnering to create healthier, more sustainable cities by focusing on prevention, community engagement, and addressing everyday factors that impact health. The Green and Thriving Neighbourhoods programme, supported by Novo Nordisk and C40, aims to create low-carbon, people-centred neighbourhoods with access to healthy food, green spaces, and safe transport. Community-led projects in Buenos Aires, Nairobi, and Rio de Janeiro are transforming urban spaces through initiatives like expanding markets for healthy food and creating communities where daily needs are within walking or biking distance. By involving residents in the design process, cities can promote health, equity, and sustainability while reducing emissions and creating environments that benefit all residents. City leaders are taking bold steps to shape healthy and sustainable living environments for urban residents, demonstrating the effectiveness of local action in influencing broader change nationally and globally.